Webb1 dec. 2024 · In 2 prior studies from the same Italian center, ELF showed excellent area under the receiver operating characteristic curve (AUROC) (>90%) for discriminating any stage of fibrosis, or clinically significant or advanced fibrosis in children and adolescents with NAFLD and elevated liver enzymes. 15, 16 There are no available multicenter data … WebbThe reference range of the ELF score overlap with the area defined as moderate fibrosis by the manufacturer. High biological variation of HA was diminished by the natural logarithm in the calculation of the ELF score. The use of the ELF score has suitable analytical and acceptable biological perform …
enhanced liver fibrosis (ELF) score - General Practice notebook
Webbthe ELF score combines quantitative serum concentration measurements of three fibrosis markers (TIMP-1, PIIINP, and HA) to a single value NICE suggest that: consider using … Webb26 juli 2015 · TE and ELF at baseline were significantly elevated compared to controls (TE: 5.9 (3.4-8.3) kPa versus 4.45 (2.45-8.85) kPa, P < 0.01; ELF: 9.0 (7.87-9.60) versus 8.6 (7.33-11.52), P = 0.033). All children with elevated TE and ELF results had normal transaminases. After the program, ELF and TE normalized. daniels-head insurance
Assessment Diagnosis Non-alcoholic fatty liver disease ... - NICE
WebbThe ELF test is a panel of three biomarkers: type III procollagen peptide (PIIINP), hyaluronic acid (HA), and tissue inhibitor of metalloproteinase-1 (TIMP1). These values are … Webb21 juli 2024 · In contrast, the median per-patient variation in ELF scores between clinic visits was approximately 3% over 12 weeks, 4% over 48 weeks, and 4% over 96 weeks. Elevated ELF scores at baseline and at weeks 12, 24 and 48, each associated with development of cirrhosis at 2 years (odds ratio >2.75; P < .01 for all timepoints). WebbAccording to manufacturer’s data, the ELF score is categorized into the following three stages: <7.7 (no or mild fibrosis), ≥7.7 to <9.8 (moderate fibrosis), and ≥9.8 (severe fibrosis) (17). An expert biochemist analyzed ELF test results independently without knowing the biopsy results or other clinical data. Statistical analyses daniels head insurance texas